Trujillo is easily accessible by road, lying along the A-5 highway that connects Madrid and Lisbon, making it a convenient stop for travelers exploring Spain and Portugal. The nearest major city is Cáceres, about 45 minutes away by car, while Madrid is roughly a two-and-a-half-hour drive. Buses connect Trujillo to Cáceres, Madrid, and other nearby towns, though there is no direct train service to the city.
For international travelers, the closest major airport is in Madrid, and from there, car rentals or bus services are the best ways to reach Trujillo. Within the city, Trujillo is best explored on foot due to its compact size and pedestrian-friendly streets. Taxis and local bus services are available for those who prefer not to walk or for visiting outlying areas.
Trujillo’s central location in Extremadura makes it a great base for exploring other attractions in the region, such as the Monfragüe National Park or the medieval city of Cáceres.