The economy of Guillena is largely driven by agriculture, with olive oil production being one of its key industries. The town is surrounded by olive groves, and local producers create high-quality olive oil that is sought after both domestically and internationally. Other agricultural products include cereals, fruits, and vegetables, which are cultivated in the fertile Guadalquivir River valley.
Tourism is another important aspect of Guillena’s economy, especially given its proximity to Seville. The town attracts visitors looking for an authentic Andalusian experience away from the hustle and bustle of larger cities. Local artisans also contribute to the economy by producing traditional crafts such as ceramics and leather goods, which are sold in markets and shops throughout the region.