Palos de la Frontera is easily accessible from major cities such as Seville and Huelva. The closest major airport is Seville Airport, approximately 100 kilometers away, which offers both domestic and international flights. From there, visitors can reach Palos de la Frontera by car, bus, or train.
Public transportation within the city includes buses, but due to its small size, many of the main attractions are easily reachable on foot. The nearby cities of Huelva and Seville offer additional transportation options, including high-speed trains and buses, making it easy to explore the surrounding areas and access the city from different parts of Spain.