Guillena is home to a population of approximately 13,000 residents. The town has a predominantly Spanish population, with a strong Andalusian cultural influence. In recent years, Guillena has experienced modest population growth, partly due to its proximity to Seville, which has attracted people looking for a quieter lifestyle while maintaining access to the opportunities and amenities of a larger city.
The demographic of the town includes a mix of young families, older residents, and a small but growing number of expatriates who have been drawn to Guillena for its charm and affordable living.