The economy of Guía de Isora is primarily driven by tourism, agriculture, and fishing. Over the years, the town has transformed into a sought-after destination for eco-tourism, luxury tourism, and wellness retreats. High-end resorts, such as the Ritz-Carlton Abama, have attracted international visitors, making tourism one of the leading industries.
Agriculture also plays a significant role in the local economy, with the area known for producing bananas, tomatoes, and other fruits, as well as wine. Traditional fishing remains important, providing fresh seafood to local restaurants and markets. The town has a growing artisanal sector, producing handicrafts and local goods, which also contribute to the economy.