Guía de Isora is easily accessible by road, with Tenerife South Airport located just 30 minutes away, making it convenient for international visitors. There are also ferry connections from other Canary Islands, and highways connect the town to major cities such as Adeje and Santa Cruz de Tenerife.
Public transportation within the town includes bus services that run regularly to nearby towns and beaches, although car rentals are highly recommended for visitors who want to explore the island at their own pace. The town is relatively small and easy to navigate, with walking being a pleasant way to explore its streets and plazas.