Villanueva de la Serena is easily accessible by road, making it well-connected to other cities in Extremadura and beyond. The city is located on the A-5 highway, which links it to Madrid and Lisbon, making it a convenient stop for travelers exploring Spain and Portugal. The nearest major airport is Badajoz Airport, about an hour away by car, with regular flights to Madrid and Barcelona. There is also a train station in the city, offering connections to larger cities such as Mérida and Madrid.
Within the city, public transportation options include buses and taxis, which make it easy to navigate. Villanueva de la Serena is also highly walkable, with most attractions, restaurants, and venues located within a short distance of each other, allowing visitors to explore the city on foot.